type	Journal Article
authors	Soda, K.; Moriguchi, M.; Tanizawa, K.
title	Regulation of the activity of microbial kynureninase by transamination of the enzyme-bound coenzyme
journal	Acta Vitaminol Enzymol
Activity	3.7.1.3
ui	78100151
year	(1975)
volume	29
number	1-6
pages	335-8
keywords	Alanine
abstract	Kynureninase was purified to homogeneity from the extracts of Pseudomonas marginalis and Neurospora crassa. The active kynureninase containing pyridoxal 5'-phosphate transaminates with L-ornithine or L- alanine to form the inactive pyridoxamine 5'-phosphate form of enzyme and delta1-pyrroline-2-carboxylate or pyruvate. This inactive enzyme transaminates with pyruvate to restore the active pyridoxal 5'- phosphate enzyme and L-alanine. The activity of kynureninase is regulated in this manner by transamination of the coenzyme moiety.
last changed	2002/11/12 16:17