type	Journal Article
authors	Kern, B. A.; Inamine, E.
title	Cystathionine gamma-lyase activity in the cephamycin C producer Streptomyces lactamdurans
journal	J Antibiot (Tokyo)
Activity	4.4.1.1
Family	4.4.1.1
ui	82007502
year	(1981)
volume	34
number	5
pages	583-9.
keywords	Antibiotics/*biosynthesis
abstract	Extracts of the cephamycin C producer S. lactamdurans were found to possess cystathionine gamma-lyase activity (E.C. 4.4.1.1). This represents the first demonstration of this enzyme of the reverse transsulfuration pathway in a prokaryotic organism. A likely involvement of reverse transsulfuration in antibiotic synthesis is indicated by the fact that propargylglycine, a mechanism-based inhibitor of the gamma-lyase, is a strong inhibitor of cephamycin C production.
last changed	2008/04/02 19:23