type	Journal Article
authors	Whalen, W. A.; Berg, C. M.
title	Gratuitous repression of avtA in Escherichia coli and Salmonella typhimurium
journal	J Bacteriol
Activity	2.6.1.66
ui	84212221
year	(1984)
volume	158
number	2
pages	571-4.
keywords	Alanine/pharmacology
abstract	avtA , which encodes transaminase C (alanine-valine transaminase), is repressed by excess-L-alanine or L-leucine, and also by limitation for any of a number of amino acids in Escherichia coli and Salmonella typhimurium. Amino acid limitation causes repression by promoting the accumulation of L-alanine or L-leucine or both. avtA is also repressed by L-alpha-aminobutyric acid and other nonprotein amino acids which are structurally similar to L-alanine. We hypothesize that L-alanine and L- alpha-aminobutyric acid, whose syntheses are catalyzed by transaminase C, are the true corepressors of avtA . Repression by structural analogs of the true corepressors is termed gratuitous repression.
last changed	2002/11/02 00:35