B6db families : 2_5_1

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2.5.1.113

Activity

2.5.1.113

Description

[CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase

Notes

This family is composed of strictrly related enzymes, from Nocardiaceae. The family is built on the validated sequence from Mycobacterium tuberculosis.

PDB

3DWI;3DKI;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type II

Number of sequences

Sequences in seed alignment

Bacteria

WP_067582222 (Nocardia terpenica); WP_005262001 (Rhodococcus opacus); NP_215852 (Mycobacterium tuberculosis H37Rv); WP_030469585 (Lechevalieria aerocolonigenes); KSU60650 (Gordonia sp. SGD-V-85); WP_068275788 (Rhodococcus kunmingensis); WP_018161125 (Smaragdicoccus niigatensis); CRY78618 (Nocardia farcinica); KLO28175 (Mycobacterium haemophilum); WP_063130592 (Nocardia fusca);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

NP_215852

Domain interval

7-295

Catalytic site

51 K

References

Agren D, Schnell R, Oehlmann W, Singh M, Schneider G. (2008) Cysteine Synthase (CysM) of Mycobacterium tuberculosis Is an O-Phosphoserine Sulfhydrylase: evidence for an alternative cysteine biosynthesis pathway in mycobacteria. J Biol Chem 283 31567-74.

O'Leary SE, Jurgenson CT, Begley TP, Ealick SE. (2008) O-phospho-L-serine and the thiocarboxylated sulfur carrier protein CysO-COSH are substrates for CysM, a cysteine synthase from Mycobacterium tuberculosis. Biochemistry 47 11606-15.

Articles on 2.5.1.113

last changed

2017/06/23 18:39