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B6db families: 2.5.1.76
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2.5.1.76
Activity 2.5.1.76
Description Cysteate synthase
Notes A small family of enzymes from Archaea (methanogens) and bacteria, related to threonine synthase (family 4.2.3.1).
PLP Fold Type II
PLP-dependent Domain
Domain alignment
Domain hmm		Fold type II
Number of sequences 10
Sequences in seed alignment
ArchaeaNP_618187 (Methanosarcina acetivorans); ABN56046 (Methanoculleus marisnigri); YP_504383 (Methanospirillum hungatei JF-1); ACL17997 (Candidatus Methanosphaerula palustris); YP_001029944 (Methanocorpusculum labreanum);
BacteriaWP_067426780 (Streptomyces lincolnensis); WP_062722964 (Streptomyces caeruleatus); SNX56812 (Streptomyces sp. TLI_55); PIG70676 (Streptomyces sp. 70); ELP62052 (Streptomyces turgidiscabies Car8);

DISPLAY: Fasta format, alignment, hmm, hmm_local
Reference sequence NP_618187
Domain interval 88-386
Catalytic site 107 K
 
References
 Wang M., Chen D, Zhao Q, Liu W (2018) Isolation, Structure Elucidation, and Biosynthesis of a Cysteate-Containing Nonribosomal Peptide in Streptomyces lincolnensis J Org Chem 83 7102-7108.

 Graham DE, Taylor SM, Wolf RZ, Namboori SC. (2009) Convergent evolution of coenzyme M biosynthesis in the Methanosarcinales: cysteate synthase evolved from an ancestral threonine synthase Biochem J 424 467-78.

Articles on 2.5.1.76
last changed 2018/07/09 13:48

B6db families