B6db families : 2_6_1

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2.6.1.105

Activity

2.6.1.105

Description

Lysine--8-amino-7-oxononanoate transaminase

Notes

Family based on the validat3ed sequence from Bacillus subtilis. Enzymes very similar to those in family 2.6.1.62, but distinct based on the fact that use L-lysine as the amino group donor.

PDB

3DOD;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

WP_061805750 (Bacillus endophyticus); G97067 (Clostridium acetobutylicum); BAC03240 (Bacillus subtilis); EME75550 (Bacillus sonorensis L12); WP_025025689 (Bacillus mannanilyticus); NP_846574 (Bacillus anthracis); BAB04501 (Bacillus halodurans); BIOA_BACSH (Bacillus sphaericus); WP_061528822 (Bacillus nakamurai); BIOA_AQUAE (Aquifex aeolicus); WP_048406785 (Bacillus glycinifermentans); EPZ38450 (Anoxybacillus sp. SK3-4);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

BAC03240

Domain interval

29-380

Catalytic site

280 K

References

Dey, S.; Lane, J.M.; Lee, R.E.; Rubin, E.J.; Sacchettini, J.C. (2010) Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase Biochemistry 49 6746-60.

Van Arsdell, SW.; Perkins, J.B.; Yocum, R.R.; Luan, L.; Howitt, C.L.; Prasad Chatterjee, N.; Pero, J.G. (2005) Removing a bottleneck in the Bacillus subtilis biotin pathway: bioA utilizes lysine rather than S-adenosylmethionine as the amino donor in the KAPA-to-DAPA reaction Biotechnol Bioeng 91 75-83.

Articles on 2.6.1.105

last changed

2017/09/05 10:02