B6db families : 2_6_1

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2.6.1.45

Activity

2.6.1.45

Description

Serine--glyoxylate aminotransferase

Notes

Sequences closely related to those of mammalian alanine-glyoxylate aminotransferase (2.6.1.44a).
The Arabidopsis enzyme also shows alanine-glyoxylate aminotransferase activity (2.6.1.44), but serine is the preferred substrate.

PDB

6PK3;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

SGAA_METEX (Methylobacterium extorquens); CAE39480 (Bordetella parapertussis); WP_010960683 (Methylococcus capsulatus); ZP_00026510 (Ralstonia metallidurans); NP_102937 (Mesorhizobium loti); WP_014149643 (Methylomicrobium alcaliphilum); WP_015950680 (Methylorubrum extorquens); SGAA_HYPME (Hyphomicrobium methylovorum); ATQ68556 (Methylosinus trichosporium OB3b); NP_436411 (Sinorhizobium meliloti);

Viridiplantae

AAQ56193 (Cucumis melo); ABK24112 (Picea sitchensis); BAB20811 (Arabidopsis thaliana); AAB95218 (Fritillaria agrestis); XP_002279236 (Vitis vinifera); BAD08917 (Oryza sativa); XP_003617296 (Medicago truncatula); NP_001237048 (Glycine max);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

SGAA_HYPME

Domain interval

7-353

Catalytic site

196 K

References

But SY, Egorova SV, Khmelenina VN, Trotsenko YA (2019) Serine-glyoxylate aminotranferases from methanotrophs using different C1-assimilation pathways Antonie Van Leeuwenhoek 112 741-751.

Liepman AH, Vijayalakshmi J, Peisach D, Hulsebus B, Olsen LJ, Saper MA (2019) Crystal Structure Of Photorespiratory Alanine:Glyoxylate Aminotransferase 1 (AGT1) From Arabidopsis thaliana Front Plant Sci 10 1229.

Zhang Z, Mao X, Ou J, Ye N, Zhang J, Peng X (2015) Distinct photorespiratory reactions are preferentially catalyzed by glutamate:glyoxylate and serine:glyoxylate aminotransferases in rice J Photochem Photobiol B 142 110-7.

Liepman, A.H.; Olsen, L.J. (2001) Peroxisomal alanine : glyoxylate aminotransferase (AGT1) is a photorespiratory enzyme with multiple substrates in Arabidopsis thaliana. Plant J 25 487-98.

Hagishita, T.; Yoshida, T.; Izumi, Y.; Mitsunaga, T. (1996) Cloning and expression of the gene for serine-glyoxylate aminotransferase from an obligate methylotroph Hyphomicrobium methylovorum GM2 Eur J Biochem 241 1-5.

Chistoserdova, L.V.; Lidstrom, M.E. (1994) Genetics of the serine cycle in Methylobacterium extorquens AM1: identification of sgaA and mtdA and sequences of sgaA, hprA, and mtdA J Bacteriol 176 1957-68.

Articles on 2.6.1.45

last changed

2019/11/22 15:22