B6db families : 2_6_1_57

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2.6.1.57 c

Activity

2.6.1.57

Description

Aromatic amino acid transaminase (family c)

Notes

This family is based on the sequence of M. tuberculosis Rv3772 and from C. glutamicum; it also includes proteins from other actinobacteria. These proteins show good similarity to the families tsra and thnj (transaminases acting on modified tryptophans) and to 2.6.1.9 (histidinol phosphate aminotransferase)

PDB

4R5Z;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

WP_036454010 (Mycobacterium smegmatis); WP_085957437 (Corynebacterium fournierii); WP_027004195 (Corynebacterium halotolerans); WP_091621656 (Amycolatopsis saalfeldensis); WP_068084678 (Mycobacterium sp. E1747); WP_070893483 (Mycobacterium tuberculosis); WP_090587156 (Mycobacterium brumae); AVL27082 (Actinoplanes tsinanensis); WP_141790172 (Oryzihumus leptocrescens); WP_003931256 (Mycobacterium vaccae); WP_030167908 (Kitasatospora arboriphila); NP_599471 (Corynebacterium glutamicum ATCC 13032); WP_047252124 (Corynebacterium testudinoris); GAB44934 (Gordonia terrae NBRC 100016); WP_028848480 (Thermocrispum agreste); WP_018582514 (Corynebacterium pilosum); SHS82941 (Mycobacterium abscessus); WP_085548938 (Corynebacterium pollutisoli);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

WP_070893483

Domain interval

22-344

Catalytic site

217 K

References

Nasir N, Anant A, Vyas R, Biswal BK (2016) Crystal structures of Mycobacterium tuberculosis HspAT and ArAT reveal structural basis of their distinct substrate specificities Sci Rep 6 18880.

Marienhagen J, Kennerknecht N, Sahm H, Eggeling L. (2005) Functional analysis of all aminotransferase proteins inferred from the genome sequence of Corynebacterium glutamicum J Bacteriol 187 7639-46.

Articles on 2.6.1.57.c

last changed

2017/10/17 09:25