B6db families : 2_8_1_7

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2.8.1.7 c

Activity

2.8.1.7

Description

Cysteine desulfurase (family c)

Notes

Very divergent family of enzymes, apparently occurring only in a few bacteria. The sequences are very distantly relted to (but shorter than) those in family 4.3.1.36.
The prototype, YcfC from Erwinia amylovora, has been implicated in the synthesis of 6-thioguanine.

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

WP_082315611 (Vibrio coralliilyticus); WP_004156388 (Erwinia amylovora); WP_092551865 (Xenorhabdus koppenhoeferi); WP_069318073 (Xenorhabdus ominickii); WP_034946285 (Erwinia oleae); WP_046221533 (Photobacterium halotolerans); WP_104087697 (Cryobacterium sp. N19); WP_053922280 (Streptomyces chattanoogensis); SMY05101 (Brevibacterium sp.239c); WP_012442179 (Erwinia tasmaniensis);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

WP_004156388

Domain interval

18-288

Catalytic site

148 K

References

Hertweck C (2018) Enzymatic Thioamide Formation in Bacterial Antimetabolite Pathway Angew Chem Int Ed Engl 57 11574-11578.

Articles on 2.8.1.7.c

last changed

2020/02/20 14:44