B6db families : 4_1_1_19

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4.1.1.19 2

Activity

4.1.1.19

Description

Arginine decarboxylase (family 2)

Notes

The family was built based on the sequence of the Escherichia coli (biodegradative) arginine decarboxylase.
The family encompasses only bacterial sequences belonging to the fold-type I group. (In contrast, plant arginine decarboxylases and the biosynthetic E. coli enzyme - included in family 4.1.1.19_1 - belong to the fold-type III group).

Note that the sequences from gram- bacteria (including E. coli) are longer than those from gram+ bacteria, mainly due to the presence of an additional N-terminal domain in the enzymes from gram- species.

PDB

2VYC;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

NP_404807 (Yersinia pestis); ZP_00060969 (Clostridium thermocellum); ZP_00171293 (Ralstonia eutropha); NP_243506 (Bacillus halodurans); SPEA_BACSU (Bacillus subtilis); ZP_00182964 (Exiguobacterium sp.); ADIA_ECOLI (Escherichia coli); NP_435607 (Sinorhizobium meliloti); Q8ZHG8 (Yersinia pestis); NP_622677 (Thermoanaerobacter tengcongensis);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

ADIA_ECOLI

Domain interval

140-607

Catalytic site

386 K

References

Counts KG, Wong I, Oliveira MA (2007) Investigating the geminal diamine intermediate of Yersinia pestis arginine decarboxylase with substrate, product, and inhibitors using single wavelength stopped-flow spectroscopy Biochemistry 46 379-86.

Stim, K.P.; Bennett, G.N. (1993) Nucleotide sequence of the adi gene, which encodes the biodegradative acid-induced arginine decarboxylase of Escherichia coli J Bacteriol 175 1221-34.

Articles on 4.1.1.19.2

last changed

2020/02/17 15:59