B6db families : 4_1_1_25

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4.1.1.25 b

Activity

4.1.1.25

Description

Tyrosine decarboxylase (family b)

Notes

This family includes solely archaeal enzymes, only distantly related to those in family a. The sequences in this family are most similar to archaeal aspartate-glutamate 1-decarboxylases.

PDB

3F9T;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Archaea

ZP_00148199 (Methanococcoides burtonii); YP_001047756 (Methanoculleus marisnigri JR1); WP_012065951 (Methanococcus vannielii); YP_008916484 (Methanobacterium sp. MB1); WP_011973718 (Methanococcus aeolicus); WP_007043501 (Methanotorris formicicus); NP_987251 (Methanococcus maripaludis); WP_013099471 (Methanocaldococcus infernus); WP_015733169 (Methanocaldococcus vulcanius); MFNA_METTP (Methanosaeta thermophila PT); WP_013180716 (Methanococcus voltae); Q60358 (Methanocaldococcus jannaschii);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

Q60358

Domain interval

11-390

Catalytic site

245 K

References

Chellam Gayathri S, Manoj N (2019) Structural insights into the mechanism of internal aldimine formation and catalytic loop dynamics in an archaeal Group II decarboxylase J Struct Biol 208 137-151.

Kezmarsky, N.D; Xu, H.; Graham, D.E.; White, R.H. (2005) Identification and characterization of a l-tyrosine decarboxylase in Methanocaldococcus jannaschii Biochim Biophys Acta 1722 175-182.

Articles on 4.1.1.25.b

last changed

2020/02/13 13:33