B6db families : 4_2_1

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4.2.1.168

Activity

4.2.1.168

Description

GDP-4-dehydro-6-deoxy-D-mannose-3-dehydratase

Notes

This enzyme is related to the E1 protein of CDP-4-dehydro-6-deoxyglucose reductase (EC 1.17.1.1) and shares with the latter the absence of an active site lysine - meaning that the cofactor is not covalently bound to the enzyme through an internal aldimine linkage.

PDB

2GMS;2GMU;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

ABS44742 (Campylobacter jejuni); YP_270852 (Colwellia psychrerythraea); AAL67563 (Escherichia coli); AAK83015 (Salmonella enterica); BAA33628 (Vibrio cholerae);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

AAL67563

Domain interval

9-388

Catalytic site

n/a

References

Cook, P.D.; Thoden, J.B.; Holden, H.M. (2006) The structure of GDP-4-keto-6-deoxy-D-mannose-3-dehydratase: a unique coenzyme B6-dependent enzyme Protein Sci 15 2093-106.

Alam J, Beyer N, Liu HW. (2004) Biosynthesis of colitose: expression, purification, and mechanistic characterization of GDP-4-keto-6-deoxy-D-mannose-3-dehydrase (ColD) and GDP-L-colitose synthase (ColC). Biochemistry 43 16450-60.

Articles on 4.2.1.168

last changed

2017/09/08 09:12