B6db families : 4_3_1_18

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4.3.1.18 b

Activity

4.3.1.18

Description

D-serine ammonia-lyase (family b)

Notes

A family of fold-type III proteins, built based on the functionally validated sequences from yeast and chicken.
These eukaryotic proteins are more closely related to those of family 4.1.2.42 (D-threonine aldolase, low specificity) than to those of bacterial D-amino acid ammonia-lyases. All three families, however, share the requirement of a divalent metal ion (in addition to PLP) for function.

PLP Fold Type

III

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type III

Number of sequences

Sequences in seed alignment

Fungi	NP_594997 (Schizosaccharomyces pombe 972h-); XP_455572 (Kluyveromyces lactis); XP_462390 (Debaryomyces hansenii); XP_001383278 (Pichia stipitis); XP_001483903 (Pichia guilliermondii); XP_001262434 (Neosartorya fischeri); NP_011319 (Saccharomyces cerevisiae); XP_445494 (Candida glabrata);
Metazoa	XP_002127262 (Ciona intestinalis); BAF95910 (Gallus gallus); AAI22307 (Danio rerio);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

NP_011319

Domain interval

8-325

Catalytic site

60 K

References

Ito T, Hemmi H, Kataoka K, Mukai Y, Yoshimura T. (2008) A novel zinc-dependent D-serine dehydratase from Saccharomyces cerevisiae Biochem J 409 399-406.

Tanaka H, Yamamoto A, Ishida T, Horiike K. (2008) D-Serine dehydratase from chicken kidney: a vertebral homologue of the cryptic enzyme from Burkholderia cepacia J Biochem 143 49-57.

Articles on 4.3.1.18.b

last changed

2017/06/14 13:06