B6db families : 4_4_1_8

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4.4.1.8 b

Activity

4.4.1.8

Description

Cystathionine beta-lyase (family b)

Notes

A family built initially around the MalY protein of E. coli, which acts as a cystathionine beta-lyase but is also involved in the regulation of the maltose operon.
The enzyme from lactobacillus sakei also shows racemase activity towards a number of amino acids.

PDB

1D2F;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

ZP_02329471 (Paenibacillus larvae); AAC44677 (Vibrio furnissii); CAD65601 (Lactobacillus plantarum WCFS1); CAB56665 (Streptomyces coelicolor A3(2)); WP_010768139 (Enterococcus phoeniculicola); YP_855967 (Aeromonas hydrophila); BAX66038 (Lactobacillus sakei subsp. sakei DSM 20017); ZP_01221379 (Photobacterium profundum); MALY_ECOLI (Escherichia coli);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

MALY_ECOLI

Domain interval

28-382

Catalytic site

233 K

References

Kato S, Oikawa T (2018) A Novel Bifunctional Amino Acid Racemase With Multiple Substrate Specificity, MalY From Lactobacillus sakei LT-13: Genome-Based Identification and Enzymological Characterization Front Microbiol 7 403.

Zdych E. Peist, R. Reidl, J. Boos, W. (1995) MalY of Escherichia coli is an enzyme with the activity of a beta C-S lyase (cystathionase) J. Bacteriol. 177 5035-5039.

Articles on 4.4.1.8.b

last changed

2018/04/09 16:34