B6db families : 5_1_1

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5.1.1.10

Activity

5.1.1.10

Description

Amino-acid racemase

Notes

Family of enzymes from thermophilic archaea, built on the validated sequence from Pyrococcus horikoshi. The sequences are strictly related to those of bacterial isoleucine 2-epimerases (Family 5.1.1.21)

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Archaea

WP_014766824 (Desulfurococcus amylolyticus); WP_014737968 (Thermogladius calderae); WP_013128880 (Thermosphaera aggregans); BAA29207 (Pyrococcus horikoshii OT3); BAA29874 (Pyrococcus horikoshii OT3); AFH42889 (Fervidicoccus fontis Kam940); WP_048146491 (Pyrococcus abyssi);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

BAA29207

Domain interval

34-447

Catalytic site

295 K

References

Kawakami, R.; Ohshida, T.; Sakuraba, H.; Ohshima, T. (2018) A Novel PLP-Dependent Alanine/Serine Racemase From the Hyperthermophilic Archaeon Pyrococcus horikoshii OT-3 Front Microbiol 9 1481.

Kawakami, R.; Sakuraba, H.; Ohmori, T.; Ohshima, T. (2017) First characterization of an archaeal amino acid racemase with broad substrate specificity from the hyperthermophile Pyrococcus horikoshii OT-3 J Biosci Bioeng 124 23-27.

Kawakami, R.; Ohmori, T.; Sakuraba H, Ohshima, T. (2015) Identification of a novel amino acid racemase from a hyperthermophilic archaeon Pyrococcus horikoshii OT-3 induced by D-amino acids Amino Acids 47 1579-87.

Articles on 5.1.1.10

last changed

2017/09/01 13:41