B6db families : 5_1_1_1

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5.1.1.1 b

Activity

5.1.1.1

Description

Alanine racemase (family b)

Notes

A family constituted by a few fungal enzymes, completely different from their bacterial counterparts and from the S. pombe sequences.

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Fungi

EER26822 (Coccidioides posadasii C735 delta SOWgp); EEP77449 (Uncinocarpus reesii); CAA02484 (Tolypocladium inflatum); AAD47837 (Cochliobolus carbonum);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

CAA02484

Domain interval

25-317

Catalytic site

220 K

References

di Salvo ML1, Florio R, Paiardini A, Vivoli M, D'Aguanno S, Contestabile R. (2013) Alanine racemase from Tolypocladium inflatum: A key PLP-dependent enzyme in cyclosporin biosynthesis and a model of catalytic promiscuity Arch Biochem Biophys 529 55-65.

Cheng, Y.Q. Walton, J.D. (2000) A eukaryotic alanine racemase gene involved in cyclic peptide biosynthesis J Biol Chem. 275 4906-4911.

Articles on 5.1.1.1.b

last changed

2018/07/10 13:45