B6db families : 5_1_1

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5.1.1.21

Activity

5.1.1.21

Description

Isoleucine 2-epimerase

Notes

Sequences most similar to those of broad-specificity amino acid racemases (grouped in family 2.6.1.10) and to those of bacterial GABA transaminases (family 2.6.1.19b).

PDB

4YSN;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

WP_009139250 (Slackia piriformis); YP_002633381 (Staphylococcus carnosus subsp. carnosus TM300); YP_007802199 (Gordonibacter pamelaeae 7-10-1-b); CCC57362 (Weissella thailandensis fsh4-2); YP_810017 (Oenococcus oeni PSU-1); WP_010021002 (Lactobacillus farciminis); WP_010008148 (Leuconostoc fallax); AGE45209 (Lactobacillus buchneri); WP_002488208 (Staphylococcus hominis);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

AGE45209

Domain interval

30-373

Catalytic site

280 K

References

Awad R, Gans P, Reiser JB (2017) Structural insights into the substrate recognition and reaction specificity of the PLP-dependent fold-type I isoleucine 2-epimerase from Lactobacillus buchneri Biochimie 137 165-173.

Hayashi J, Mutaguchi Y, Minemura Y, Nakagawa N, Yoneda K, Ohmori T, Ohshima T, Sakuraba H (2017) Crystal structure of the novel amino-acid racemase isoleucine 2-epimerase from Lactobacillus buchneri Acta Crystallogr D Struct Biol 73 428-437.

Mutaguchi Y, Ohmori T, Wakamatsu T, Doi K, Ohshima T. (2013) Identification, purification, and characterization of a novel amino acid racemase, isoleucine 2-epimerase, from Lactobacillus species. J Bacteriol. 195 5207-15.

Articles on 5.1.1.21

last changed

2019/09/18 10:43