|
|
| |
5.4.3.4 |
| Activity |
5.4.3.4 |
| Description |
D-lysine 5,6-aminomutase |
| Notes |
Lysine 5,6-aminomutase, an adenosylcobalamin and pyridoxal-5'-phosphate-dependent enzyme, is made of two subunits.
PLP is inserted in the TIM-like barrel of the alfa subunit, but is covalently bound to a Lys residue of the Rossmann domain of the beta subunit.
Only sequences of the alfa subunit have been included in this family. |
| PDB |
1XRS; |
| PLP Fold Type |
VI |
| PLP-dependent Domain |
|
| Number of sequences |
7 |
| Sequences in seed alignment |
|
| Reference sequence |
AAC79717 |
| Domain interval |
151-437 |
| Catalytic site |
n/a |
| | |
|---|
| References |
Berkovitch, F.; Behshad, E.; Tang, K.H.; Enns, E.A.; Frey, P.A.; Drennan, C.L.
(2004) A locking mechanism preventing radical damage in the absence of substrate, as revealed by the x-ray structure of lysine 5,6-aminomutase Proc Natl Acad Sci U S A 101 15870-5. Tang, K. H.; Harms, A.; Frey, P. A.
(2002) Identification of a novel pyridoxal 5'-phosphate binding site in adenosylcobalamin-dependent lysine 5,6-aminomutase from Porphyromonas gingivalis Biochemistry 41 8767-76. |
| last changed |
2009/07/03 15:03 |
|
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