B6db families : cqsa

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cqsa

Activity

Description

Acyl-CoA:L-2-aminobutyrate C-acyltransferase (decarboxylating) (2.3.1.-)

Notes

A small family of bacterial enzymes, built based on the validated sequence from Vibrio cholerae. Sequences closely resembling bacterial serine C-palmitoyltransferases (family 2.3.1.50c) and 8-amino-7-oxononanoate synthases (2.3.1.47).

PDB

2WKA;2WK8;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

YP_096734 (Legionella pneumophila); NP_232914 (Vibrio cholerae); EED27463 (Vibrio parahaemolyticus); CQSA_VIBHB (Vibrio harveyi); ACD89578 (Chlorobium limicola); ZP_00990208 (Vibrio splendidus); ZP_01385258 (Chlorobium ferrooxidans); ZP_01866959 (Vibrio shilonii); EAR21812 (Nitrococcus mobilis); CAG23609 (Photobacterium profundum); ACF45719 (Prosthecochloris aestuarii); EDP59323 (Vibrio campbellii);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

NP_232914

Domain interval

39-310

Catalytic site

236 K

References

Jahan N, Potter JA, Sheikh MA, Botting CH, Shirran SL, Westwood NJ, Taylor GL (2009) Insights into the Biosynthesis of the Vibrio cholerae Major Autoinducer CAI-1 from the Crystal Structure of the PLP-Dependent Enzyme CqsA J Mol Biol 393 763-73.

Kelly RC, Bolitho ME, Higgins DA, Lu W, Ng WL, Jeffrey PD, Rabinowitz JD, Semmelhack MF, Hughson FM, Bassler BL. (2009) The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA Nat Chem Biol 5 891-5.

Spirig T, Tiaden A, Kiefer P, Buchrieser C, Vorholt JA, Hilbi H. (2008) The Legionella autoinducer synthase LqsA produces an alpha-hydroxyketone signaling molecule J Biol Chem 283 18113-23.

Articles on cqsa

last changed

2016/10/04 14:54