B6db families : dhph-n

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dhph-n

Activity

Description

1-amino-2-(phosphohydroxy)ethyl-phosphonate phospho-lyase (4.2.3.-)

Notes

Small family, based on the validated DhpH sequence from Streptomyces luridus. The the C-terminal domain, responsible for the transpeptidase activity of these enzymes, has been removed from the sequences.

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

WP_051819677 (Streptomyces sp. NRRL S-920); WP_078870180 (Streptomyces sp. NRRL F-3213); ACZ13459 (Streptomyces luridus);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

ACZ13459

Domain interval

15-329

Catalytic site

187 K

References

Bougioukou DJ, Mukherjee S, van der Donk WA (2013) Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway Proc Natl Acad Sci U S A 110 10952-7.

Articles on dhph-n

last changed

2018/02/06 13:41