B6db families : odcp

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odcp

Activity

Description

Ornithine decarboxylase paralogue

Notes

These metazoan proteins are fold-type III, similar to lysine and ornithine decarboxylases (families 4.1.1.18 and 4.1.17_1).

However, experimental data show that THESE PROTEINS ARE NOT ENZYMES. Rather, they act as ANTIZYME INHIBITORS, and are apparently involved in the regulation of polyamine biosynthesis

PDB

4ZGZ;

PLP Fold Type

III

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type III

Number of sequences

Sequences in seed alignment

Metazoa

XP_026780062 (Pangasianodon hypophthalmus); NP_766463 (Mus musculus); NP_001008729 (Gallus gallus); XP_535320 (Canis familiaris); NP_001087584 (Xenopus laevis); NP_001280682 (Columba livia); NP_001280585 (Gallus gallus); NP_001017568 (Danio rerio); NP_001278354 (Canis familiaris); NP_001095928 (Mus musculus); NP_056962 (Homo sapiens); NP_001278589 (Columba livia); AAQ62560 (Homo sapiens); NP_001278688 (Alligator mississippiensis); XP_029592302 (Salmo trutta);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

AAQ62560

Domain interval

45-283

Catalytic site

n/a

References

Rajput B, Murphy TD, Pruitt KD (2015) RefSeq curation and annotation of antizyme and antizyme inhibitor genes in vertebrates Nucleic Acids Res 43 7270-9.

Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC. (2008) Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase Biochem J 409 187-92.

López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R. (2006) Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity J Biol Chem 281 30896-906.

Koguchi K, Kobayashi S, Hayashi T, Matsufuji S, Murakami Y, Hayashi S. (1997) Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor Biochim Biophys Acta 1353 209-16.

Articles on odcp

last changed

2018/07/18 14:30