B6db families : pctv

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pctv

Activity

pctv

Description

3-aminobenzoate synthase (2.6.1.-)

Notes

Small family of sequences from Streptomycetes, built based on the functionally validated enzyme from S. pactum

PDB

4ZM3;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

BAF92604 (Streptomyces pactum); WP_063788694 (Streptomyces griseoruber); WP_010359163 (Streptomyces acidiscabies); PWG14293 (Streptomyces sp. V2); WP_067252539 (Streptomyces sp. DSM 15324);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

BAF92604

Domain interval

40-372

Catalytic site

276 K

References

Hirayama A, Miyanaga A, Kudo F, Eguchi T (2015) Mechanism-Based Trapping of the Quinonoid Intermediate by Using the K276R Mutant of PLP-Dependent 3-Aminobenzoate Synthase PctV in the Biosynthesis of Pactamycin Chembiochem 16 2484-90.

Hirayama A, Eguchi T, Kudo F. (2013) A single PLP-dependent enzyme PctV catalyzes the transformation of 3-dehydroshikimate into 3-aminobenzoate in the biosynthesis of pactamycin. Chembiochem. 14 1198-203.

Articles on pctv

last changed

2019/05/08 13:02