B6db families : rubn4

	Activities \| Families \| Sequences \| Fold types \| References \| Help

rubn4

Activity

Description

dTDP-3,4-didehydro-2,6-dideoxy-D-glucose aminotransferase (2.6.1.-)

Notes

A small family of bacterial enzymes, strictly related to enzymes (such as 2.6.1.89 and 2.6.1.106) that also produce TTP-3-amino-deoxyhexoses.

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

AAP85347 (Streptomyces griseoruber); ZP_04032501 (Thermomonospora curvata); ABV49595 (Streptomyces eurythermus); EEK34299 (Nocardiopsis dassonvillei); YP_001537186 (Salinispora arenicola); ACB37737 (Micromonospora chalcea); BAC79028 (Streptomyces sp. AM-7161); CAI94698 (Streptomyces achromogenes subsp. rubradiris); DNRJ_STRPE (Streptomyces peucetius); ACB46490 (Actinomadura kijaniata); AAG13910 (Micromonospora megalomicea); CAA11782 (Amycolatopsis orientalis); AVO00806 (Streptomyces sp. 120454); BAB72037 (Streptomyces galilaeus); CAC48376 (Amycolatopsis balhimycina);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

CAI94698

Domain interval

13-367

Catalytic site

186 K

References

Lamichhane J, Liou K, Lee HC, Kim CG, Sohng JK. (2006) Functional characterization of ketoreductase (rubN6) and aminotransferase (rubN4) genes in the gene cluster of Streptomyces achromogenes var. rubradiris Biotechnol Lett 28 545-53.

Chen H, Thomas MG, Hubbard BK, Losey HC, Walsh CT, Burkart MD. (2000) Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis Proc Natl Acad Sci U S A 97 11942-7.

Articles on rubn4

last changed

2014/08/19 13:41