B6db families : tsra

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tsra

Activity

Description

2-methyltriptophan aminotransferase (2.6.1.-)

Notes

Small family built around the single validated sequence from Streptomyces laurentii. Distantly similar to beta-methylpyruvate aminotransferase (marg) and histidinol-phosphate aminotransferase (2.6.1.9).

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

ACN80638 (Streptomyces sioyaensis); SED63177 (Streptomyces sp. 2314.4); ACN80663 (Streptomyces laurentii); WP_059424795 (Streptomyces azureus);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

ACN80663

Domain interval

15-333

Catalytic site

204 K

References

Lin Z, Ji J, Zhou S, Zhang F, Wu J, Guo Y, Liu W (2017) Processing 2-Methyl-l-Tryptophan through Tandem Transamination and Selective Oxygenation Initiates Indole Ring Expansion in the Biosynthesis of Thiostrepton J Am Chem Soc 39 12105-12108.

Kelly WL, Pan L, Li C. (2009) Thiostrepton biosynthesis: prototype for a new family of bacteriocins J Am Chem Soc 131 4327-34.

Articles on tsra

last changed

2017/09/04 13:18