B6db families : uncharacterized_family

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uncharacterized family yhfs

Activity

Description

unclassified activities

Notes

Very distinct family of bacterial proteins, built based on Yhfs from E. coli (whose structure is known). Sequences in this family are distantly related to methionine gamma-lyases (family 4.4.1.11) and other C-S lyases, but also to the mocr group of proteins.

Under anaerobiosis, yhfS gene expression is activated by the transcriptional activator FNR. A ΔyhfS mutant has aggravating genetic interactions with genes involved in DNA recombination (source: https://biocyc.org/gene?orgid=ECOLI&id=G7728)

The yhfs genes normally cluster together with genes of the yhfx family (see unclassified_family_yhfx). The connection is particularly evident in firmicutes such as Lactobacillus rhamnosum, Jeotgalibaca dankookensis, Carnobacterium sp AT7.

PDB

4J8L;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

WP_012859840 (Sebaldella termitidis); WP_062742191 (Enterobacter lignolyticus); WP_005714935 (Lactobacillus rhamnosus); WP_054177853 (Trabulsiella odontotermitis); WP_062532504 (Jeotgalibaca dankookensis); WP_012382302 (Streptomyces griseus); WP_011245531 (Bacillus clausii); P45545 (Escherichia coli); WP_009051932 (Thermoanaerobacter sp. X514); YP_805681 (Lactobacillus paracasei ATCC 334); ZP_03568370 (Atopobium rimae ATCC 49626); WP_049114522 (Klebsiella michiganensis); WP_007723438 (Carnobacterium sp. AT7); WP_043018560 (Citrobacter freundii); WP_078697406 (Caloramator quimbayensis);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

P45545

Domain interval

39-236

Catalytic site

196 K

References

Articles on uncharacterized.family.yhfs

last changed

2018/02/09 10:49