B6db activities : 2_3_1

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	2.3.1.37
Description	5-aminolevulinic acid synthase
Alternative names	Delta-aminolevulinate synthase; Delta-Ala synthetase; ALAS.
Catalyzed reaction	Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2).
Cofactor	Pyridoxal-phosphate.
Comments	-!- The enzyme in erythrocytes is genetically distinct from that in other tissues.
	Certain aminolevulinate synthases (e.g., the enzyme from Streptomyces aizunensis) also catalyze the cyclization of ALA-CoA to form 2-amino-3-hydroxycyclopent-2-en-1-one. This five membered ring is a precursor for many secondary metabolites including asukamycin.
Diseases	X-linked sideroblastic anemia (XLSA)
Prosite	PROSITE; PDOC00518;
PDB	2BWP; 5TXT;
Organisms	-Eubacteria -Plants -Fungi -Metazoa -Human
Family	2.3.1.37 (0)

Links	Enzyme (activities) 2.3.1.37 BRENDA (activities) 2.3.1.37 KEGG (pathways) 2.3.1.37 PLPMDB (PLP mutants) 2.3.1.37

References	Articles on 2.3.1.37

last changed	2018/05/07 09:12

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