Activities | Families | Sequences | Fold types | References | Help
B6db activities:
Description 5-aminolevulinic acid synthase.
Alternative names Delta-aminolevulinate synthase;
Delta-Ala synthetase;
Catalyzed reaction Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2).
Cofactor Pyridoxal-phosphate.
Comments -!- The enzyme in erythrocytes is genetically distinct from that in other tissues.
Diseases X-linked sideroblastic anemia (XLSA)
Prosite PROSITE; PDOC00518;
PDB 1H7J; 1H7D;
Organisms -Eubacteria -Plants -Fungi -Metazoa -Human

Family (31)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Zhang L, Chen J, Chen N, Sun J, Zheng P, Ma Y. (2013) Cloning of two 5-aminolevulinic acid synthase isozymes HemA and HemO from Rhodopseudomonas palustris with favorable characteristics for 5-aminolevulinic acid production. Biotechnol Lett. 35 763-8.

 Astner I, Schulze JO, van den Heuvel J, Jahn D, Schubert WD, Heinz DW. (2005) Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans EMBO J 24 3166-77.

 Goodfellow, B. J.; Dias, J. S.; Ferreira, G. C.; Henklein, P.; Wray, V.; Macedo, A. L. (2001) The solution structure and heme binding of the presequence of murine 5- aminolevulinate synthase FEBS Lett 505 325-31.

 Elrod, S.L.; Jones, A.; Berka, R.M.; Cherry, J.R. (2000) Cloning of the Aspergillus oryzae 5-aminolevulinate synthase gene and its use as a selectable marker Curr Genet 38 291-98.

 Bolt, E. L.; Kryszak, L.; Zeilstra-Ryalls, J.; Shoolingin-Jordan, P. M.; Warren, M. J. (1999) Characterization of the rhodobacter sphaeroides 5-aminolaevulinic acid synthase isoenzymes, HemA and HemT, isolated from recombinant Escherichia coli Eur J Biochem 265 290-9.

 Ferreira, G. C.; Dailey, H. A. (1993) Expression of mammalian 5-aminolevulinate synthase in Escherichia coli. Overproduction, purification, and characterization J Biol Chem 268 584-90.

Articles on
last changed 2010/01/27 18:08

B6db activities