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B6db activities: 2.3.1.37

2.3.1.37
Description 5-aminolevulinic acid synthase.
Alternative names Delta-aminolevulinate synthase;
Delta-Ala synthetase;
ALAS.
Catalyzed reaction Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2).
Cofactor Pyridoxal-phosphate.
Comments -!- The enzyme in erythrocytes is genetically distinct from that in other tissues.
Diseases X-linked sideroblastic anemia (XLSA)
Prosite PROSITE; PDOC00518;
PDB 1H7J; 1H7D;
Organisms -Eubacteria -Plants -Fungi -Metazoa -Human
 

Family 

2.3.1.37 (31)
 
Links Enzyme (activities) 2.3.1.37
BRENDA (activities) 2.3.1.37
KEGG (pathways) 2.3.1.37
PLPMDB (PLP mutants) 2.3.1.37
 
References
 Zhang L, Chen J, Chen N, Sun J, Zheng P, Ma Y. (2013) Cloning of two 5-aminolevulinic acid synthase isozymes HemA and HemO from Rhodopseudomonas palustris with favorable characteristics for 5-aminolevulinic acid production. Biotechnol Lett. 35 763-8.

 Astner I, Schulze JO, van den Heuvel J, Jahn D, Schubert WD, Heinz DW. (2005) Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans EMBO J 24 3166-77.

 Goodfellow, B. J.; Dias, J. S.; Ferreira, G. C.; Henklein, P.; Wray, V.; Macedo, A. L. (2001) The solution structure and heme binding of the presequence of murine 5- aminolevulinate synthase FEBS Lett 505 325-31.

 Elrod, S.L.; Jones, A.; Berka, R.M.; Cherry, J.R. (2000) Cloning of the Aspergillus oryzae 5-aminolevulinate synthase gene and its use as a selectable marker Curr Genet 38 291-98.

 Bolt, E. L.; Kryszak, L.; Zeilstra-Ryalls, J.; Shoolingin-Jordan, P. M.; Warren, M. J. (1999) Characterization of the rhodobacter sphaeroides 5-aminolaevulinic acid synthase isoenzymes, HemA and HemT, isolated from recombinant Escherichia coli Eur J Biochem 265 290-9.

 Ferreira, G. C.; Dailey, H. A. (1993) Expression of mammalian 5-aminolevulinate synthase in Escherichia coli. Overproduction, purification, and characterization J Biol Chem 268 584-90.

Articles on 2.3.1.37
 
last changed 2010/01/27 18:08

B6db activities