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B6db activities:
Description 5-aminolevulinic acid synthase
Alternative names Delta-aminolevulinate synthase;
Delta-Ala synthetase;
Catalyzed reaction Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2).
Cofactor Pyridoxal-phosphate.
Comments -!- The enzyme in erythrocytes is genetically distinct from that in other tissues.
Certain aminolevulinate synthases (e.g., the enzyme from Streptomyces aizunensis) also catalyze the cyclization of ALA-CoA to form 2-amino-3-hydroxycyclopent-2-en-1-one. This five membered ring is a precursor for many secondary metabolites including asukamycin.
Diseases X-linked sideroblastic anemia (XLSA)
Prosite PROSITE; PDOC00518;
Organisms -Eubacteria -Plants -Fungi -Metazoa -Human

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
References Articles on
last changed 2018/05/07 09:12

B6db activities