B6db activities : 2_3_1

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	2.3.1.37
Description	5-aminolevulinic acid synthase
Alternative names	Delta-aminolevulinate synthase; Delta-Ala synthetase; ALAS.
Catalyzed reaction	Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2).
Cofactor	Pyridoxal-phosphate.
Comments	-!- The enzyme in erythrocytes is genetically distinct from that in other tissues.
	Certain aminolevulinate synthases (e.g., the enzyme from Streptomyces aizunensis) also catalyze the cyclization of ALA-CoA to form 2-amino-3-hydroxycyclopent-2-en-1-one. This five membered ring is a precursor for many secondary metabolites including asukamycin.
Diseases	X-linked sideroblastic anemia (XLSA)
Prosite	PROSITE; PDOC00518;
PDB	2BWP; 5TXT;
Organisms	-Eubacteria -Plants -Fungi -Metazoa -Human
Family	2.3.1.37 (0)

Links	Enzyme (activities) 2.3.1.37 BRENDA (activities) 2.3.1.37 KEGG (pathways) 2.3.1.37 PLPMDB (PLP mutants) 2.3.1.37

References	Brown BL, Kardon JR, Sauer RT, Baker TA (2018) Structure of the Mitochondrial Aminolevulinic Acid Synthase, a Key Heme Biosynthetic Enzyme Structure 26 580-589. Hanh NPK, Hwang JY, Oh HR, Kim GJ, Choi H, Nam DH (2018) Biosynthesis of 2-amino-3-hydroxycyclopent-2-enone moiety of bafilomycin in Kitasatospora cheerisanensis KCTC2395. 2 J Microbiol 56 571-578. Bishop DF, Tchaikovskii V, Nazarenko I, Desnick RJ (2013) Molecular expression and characterization of erythroid-specific 5-aminolevulinate synthase gain-of-function mutations causing X-linked protoporphyria Mol Med 5 18-25. Zhang L, Chen J, Chen N, Sun J, Zheng P, Ma Y. (2013) Cloning of two 5-aminolevulinic acid synthase isozymes HemA and HemO from Rhodopseudomonas palustris with favorable characteristics for 5-aminolevulinic acid production Biotechnol Lett 35 763-8. Zhang W, Bolla ML, Kahne D, Walsh CT. (2010) A three enzyme pathway for 2-amino-3-hydroxycyclopent-2-enone formation and incorporation in natural product biosynthesis J Am Chem Soc 132 6402-11. Lin J, Fu W, Cen P (2009) Characterization of 5-aminolevulinate synthase from Agrobacterium radiobacter, screening new inhibitors for 5-aminolevulinate dehydratase from Escherichia coli and their potential use for high 5-aminolevulinate production Bioresour Technol 100 2293-7. Petrícek M, Petrícková K, Havlícek L, Felsberg J (2006) Occurrence of two 5-aminolevulinate biosynthetic pathways in Streptomyces nodosus subsp. asukaensis is linked with the production of asukamycin J Bacteriol 188 5113-23. Astner I, Schulze JO, van den Heuvel J, Jahn D, Schubert WD, Heinz DW. (2005) Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans EMBO J 24 3166-77. Varadharajan S, Dhanasekaran S, Bonday ZQ, Rangarajan PN, Padmanaban G (2002) Involvement of delta-aminolaevulinate synthase encoded by the parasite gene in de novo haem synthesis by Plasmodium falciparum Biochem J 367 321-7. Goodfellow, B. J.; Dias, J. S.; Ferreira, G. C.; Henklein, P.; Wray, V.; Macedo, A. L. (2001) The solution structure and heme binding of the presequence of murine 5- aminolevulinate synthase FEBS Lett 505 325-31. Elrod, S.L.; Jones, A.; Berka, R.M.; Cherry, J.R. (2000) Cloning of the Aspergillus oryzae 5-aminolevulinate synthase gene and its use as a selectable marker Curr Genet 38 291-98. Bolt, E. L.; Kryszak, L.; Zeilstra-Ryalls, J.; Shoolingin-Jordan, P. M.; Warren, M. J. (1999) Characterization of the rhodobacter sphaeroides 5-aminolaevulinic acid synthase isoenzymes, HemA and HemT, isolated from recombinant Escherichia coli Eur J Biochem 265 290-9. Ferreira, G. C.; Dailey, H. A. (1993) Expression of mammalian 5-aminolevulinate synthase in Escherichia coli. Overproduction, purification, and characterization J Biol Chem 268 584-90. Articles on 2.3.1.37

last changed	2018/05/07 09:12

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