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B6db activities:
Description 5-aminolevulinic acid synthase
Alternative names Delta-aminolevulinate synthase;
Delta-Ala synthetase;
Catalyzed reaction Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2).
Cofactor Pyridoxal-phosphate.
Comments -!- The enzyme in erythrocytes is genetically distinct from that in other tissues.
Certain aminolevulinate synthases (e.g., the enzyme from Streptomyces aizunensis) also catalyze the cyclization of ALA-CoA to form 2-amino-3-hydroxycyclopent-2-en-1-one. This five membered ring is a precursor for many secondary metabolites including asukamycin.
Diseases X-linked sideroblastic anemia (XLSA)
Prosite PROSITE; PDOC00518;
Organisms -Eubacteria -Plants -Fungi -Metazoa -Human

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Brown BL, Kardon JR, Sauer RT, Baker TA (2018) Structure of the Mitochondrial Aminolevulinic Acid Synthase, a Key Heme Biosynthetic Enzyme Structure 26 580-589.

 Hanh NPK, Hwang JY, Oh HR, Kim GJ, Choi H, Nam DH (2018) Biosynthesis of 2-amino-3-hydroxycyclopent-2-enone moiety of bafilomycin in Kitasatospora cheerisanensis KCTC2395. 2 J Microbiol 56 571-578.

 Bishop DF, Tchaikovskii V, Nazarenko I, Desnick RJ (2013) Molecular expression and characterization of erythroid-specific 5-aminolevulinate synthase gain-of-function mutations causing X-linked protoporphyria Mol Med 5 18-25.

 Zhang L, Chen J, Chen N, Sun J, Zheng P, Ma Y. (2013) Cloning of two 5-aminolevulinic acid synthase isozymes HemA and HemO from Rhodopseudomonas palustris with favorable characteristics for 5-aminolevulinic acid production Biotechnol Lett 35 763-8.

 Zhang W, Bolla ML, Kahne D, Walsh CT. (2010) A three enzyme pathway for 2-amino-3-hydroxycyclopent-2-enone formation and incorporation in natural product biosynthesis J Am Chem Soc 132 6402-11.

 Lin J, Fu W, Cen P (2009) Characterization of 5-aminolevulinate synthase from Agrobacterium radiobacter, screening new inhibitors for 5-aminolevulinate dehydratase from Escherichia coli and their potential use for high 5-aminolevulinate production Bioresour Technol 100 2293-7.

 Petrícek M, Petrícková K, Havlícek L, Felsberg J (2006) Occurrence of two 5-aminolevulinate biosynthetic pathways in Streptomyces nodosus subsp. asukaensis is linked with the production of asukamycin J Bacteriol 188 5113-23.

 Astner I, Schulze JO, van den Heuvel J, Jahn D, Schubert WD, Heinz DW. (2005) Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans EMBO J 24 3166-77.

 Varadharajan S, Dhanasekaran S, Bonday ZQ, Rangarajan PN, Padmanaban G (2002) Involvement of delta-aminolaevulinate synthase encoded by the parasite gene in de novo haem synthesis by Plasmodium falciparum Biochem J 367 321-7.

 Goodfellow, B. J.; Dias, J. S.; Ferreira, G. C.; Henklein, P.; Wray, V.; Macedo, A. L. (2001) The solution structure and heme binding of the presequence of murine 5- aminolevulinate synthase FEBS Lett 505 325-31.

 Elrod, S.L.; Jones, A.; Berka, R.M.; Cherry, J.R. (2000) Cloning of the Aspergillus oryzae 5-aminolevulinate synthase gene and its use as a selectable marker Curr Genet 38 291-98.

 Bolt, E. L.; Kryszak, L.; Zeilstra-Ryalls, J.; Shoolingin-Jordan, P. M.; Warren, M. J. (1999) Characterization of the rhodobacter sphaeroides 5-aminolaevulinic acid synthase isoenzymes, HemA and HemT, isolated from recombinant Escherichia coli Eur J Biochem 265 290-9.

 Ferreira, G. C.; Dailey, H. A. (1993) Expression of mammalian 5-aminolevulinate synthase in Escherichia coli. Overproduction, purification, and characterization J Biol Chem 268 584-90.

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last changed 2018/05/07 09:12

B6db activities