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2.3.1.37 |
Description |
5-aminolevulinic acid synthase |
Alternative names |
Delta-aminolevulinate synthase; Delta-Ala synthetase; ALAS. |
Catalyzed reaction |
Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2). |
Cofactor |
Pyridoxal-phosphate. |
Comments |
-!- The enzyme in erythrocytes is genetically distinct from that in other tissues. |
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Certain aminolevulinate synthases (e.g., the enzyme from Streptomyces aizunensis) also catalyze the cyclization of ALA-CoA to form 2-amino-3-hydroxycyclopent-2-en-1-one. This five membered ring is a precursor for many secondary metabolites including asukamycin. |
Diseases |
X-linked sideroblastic anemia (XLSA) |
Prosite |
PROSITE; PDOC00518; |
PDB |
2BWP; 5TXT; |
Organisms |
-Eubacteria -Plants -Fungi -Metazoa -Human |
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Family |
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Links |
Enzyme (activities) 2.3.1.37
BRENDA (activities) 2.3.1.37
KEGG (pathways) 2.3.1.37
PLPMDB (PLP mutants) 2.3.1.37
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References |
Articles on 2.3.1.37 |
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last changed |
2018/05/07 09:12 |
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