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4.1.1.22 |
| Description |
Histidine decarboxylase |
| Alternative names |
HDC.
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| Catalyzed reaction |
L-histidine = histamine + CO(2). |
| Cofactor |
Pyridoxal-phosphate or Pyruvate. |
| Comments |
Enzymes from gram-positive bacteria employ a pyruvoyl cofactor instead of of PLP.
In animals the enzyme is essential for the production of histamine, which plays crucial roles in intercellular communication and inflammatory processes.
The significance of histidine decarboxylase in bacteria is more obscure, but at least in some cases the enzyme represents a virulence factor.
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| Prosite |
PROSITE; PDOC00329; |
| PDB |
4E10; |
| Organisms |
-Eubacteria -Plants -Metazoa -Human |
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| Links |
Enzyme (activities) 4.1.1.22
BRENDA (activities) 4.1.1.22
KEGG (pathways) 4.1.1.22
PLPMDB (PLP mutants) 4.1.1.22
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| References |
Articles on 4.1.1.22 |
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| last changed |
2019/06/20 12:00 |
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