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B6db activities: 4.2.1.164

4.2.1.164
Description dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase
Alternative names TDP-4-oxo-2,6-dideoxy-D-glucose 3-dehydratase;
spnQ (gene name);
Catalyzed reaction dTDP-4-dehydro-2,6-dideoxy-α-D-threo-hexopyranose + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = dTDP-4-dehydro-2,3,6-trideoxy-α-D-hexopyranose + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster
Cofactor Pyridoxamine-phosphate and iron-sulfur cluster.
Comments The enzyme, isolated from the bacterium Saccharopolyspora spinosa, participates in the biosynthesis of forosamine. Requires ferredoxin/ferredoxin reductase or flavodoxin/flavodoxin reductase.
The reaction mechanism is analogous to that of CDP-6-deoxy-L-threo-D-glycero-4-hexulose 3-dehydrase (E.C. 1.17.1.1).

This enzyme is involved in the biosynthesis of forosamine, a highly deoxygenated sugar found in several natural products, such as the insecticide spinosyns.
The reaction product (dTDP-4-dehydro-2,3,6-trideoxy-d-glucose) is the substrate of the transaminase SpnR (family 2.6.1.110)

Organisms -Eubacteria
 

Family 

4.2.1.164 (0)
 
Links Enzyme (activities) 4.2.1.164
BRENDA (activities) 4.2.1.164
KEGG (pathways) 4.2.1.164
PLPMDB (PLP mutants) 4.2.1.164
 
References Articles on 4.2.1.164
 
last changed 2019/06/06 11:23

B6db activities