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4.2.1.164 |
Description |
dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase |
Alternative names |
TDP-4-oxo-2,6-dideoxy-D-glucose 3-dehydratase;
spnQ (gene name);
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Catalyzed reaction |
dTDP-4-dehydro-2,6-dideoxy-α-D-threo-hexopyranose + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = dTDP-4-dehydro-2,3,6-trideoxy-α-D-hexopyranose + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster |
Cofactor |
Pyridoxamine-phosphate and iron-sulfur cluster. |
Comments |
The enzyme, isolated from the bacterium Saccharopolyspora spinosa, participates in the biosynthesis of forosamine. Requires ferredoxin/ferredoxin reductase or flavodoxin/flavodoxin reductase. |
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The reaction mechanism is analogous to that of CDP-6-deoxy-L-threo-D-glycero-4-hexulose 3-dehydrase (E.C. 1.17.1.1).
This enzyme is involved in the biosynthesis of forosamine, a highly deoxygenated sugar found in several natural products, such as the insecticide spinosyns.
The reaction product (dTDP-4-dehydro-2,3,6-trideoxy-d-glucose) is the substrate of the transaminase SpnR (family 2.6.1.110) |
Organisms |
-Eubacteria |
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Family |
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Links |
Enzyme (activities) 4.2.1.164
BRENDA (activities) 4.2.1.164
KEGG (pathways) 4.2.1.164
PLPMDB (PLP mutants) 4.2.1.164
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References |
Articles on 4.2.1.164 |
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last changed |
2019/06/06 11:23 |
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