Activities | Families | Sequences | Fold types | References | Help
B6db activities:
Description dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase
Alternative names TDP-4-oxo-2,6-dideoxy-D-glucose 3-dehydratase;
spnQ (gene name);
Catalyzed reaction dTDP-4-dehydro-2,6-dideoxy-α-D-threo-hexopyranose + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = dTDP-4-dehydro-2,3,6-trideoxy-α-D-hexopyranose + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster
Cofactor Pyridoxamine-phosphate and iron-sulfur cluster.
Comments The enzyme, isolated from the bacterium Saccharopolyspora spinosa, participates in the biosynthesis of forosamine. Requires ferredoxin/ferredoxin reductase or flavodoxin/flavodoxin reductase.
The reaction mechanism is analogous to that of CDP-6-deoxy-L-threo-D-glycero-4-hexulose 3-dehydrase (E.C.

This enzyme is involved in the biosynthesis of forosamine, a highly deoxygenated sugar found in several natural products, such as the insecticide spinosyns.
The reaction product (dTDP-4-dehydro-2,3,6-trideoxy-d-glucose) is the substrate of the transaminase SpnR (family

Organisms -Eubacteria

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
References Articles on
last changed 2019/06/06 11:23

B6db activities