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B6db activities:
Description Histidine decarboxylase
Alternative names HDC.
Catalyzed reaction L-histidine = histamine + CO(2).
Cofactor Pyridoxal-phosphate or Pyruvate.
Comments Enzymes from gram-positive bacteria employ a pyruvoyl cofactor instead of of PLP.

In animals the enzyme is essential for the production of histamine, which plays crucial roles in intercellular communication and inflammatory processes.
The significance of histidine decarboxylase in bacteria is more obscure, but at least in some cases the enzyme represents a virulence factor.

Prosite PROSITE; PDOC00329;
PDB 4E10;
Organisms -Eubacteria -Plants -Metazoa -Human


Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Sattely ES, Walsh CT (2008) A latent oxazoline electrophile for N-O-C bond formation in pseudomonine biosynthesis J Am Chem Soc 130 12282-4.

 Morii H, Kasama K, Herrera-Espinoza R. (2006) Cloning and sequencing of the histidine decarboxylase gene from Photobacterium phosphoreum and its functional expression in Escherichia coli J Food Prot 69 1768-76.

 Moya-Garcia AA, Medina MA, Sánchez-Jiménez F. (2005) Mammalian histidine decarboxylase: from structure to function Bioessays 27 57-63.

 Rodriguez-Caso, C.; Rodriguez-Agudo, D.; Moya-Garcia, A.A., Fajardo, I.; Medina, M.A.; Subramaniam, V.; Sanchez-Jimenez, F. (2003) Local changes in the catalytic site of mammalian histidine decarboxylase can affect its global conformation and stability Eur J Biochem 270 4376-87.

 Tolmasky, M.E.; Actis, L.A.; Crosa, J.H. (1995) A histidine decarboxylase gene encoded by the Vibrio anguillarum plasmid pJM1 is essential for virulence: histamine is a precursor in the biosynthesis of anguibactin Mol Microbio 15 87-95.

 Yatsunami, K.; Tsuchikawa, M.; Kamada, M.; Hori, K.; Higuchi, T. (1995) Comparative studies of human recombinant 74- and 54-kDa L-histidine decarboxylases J Biol Chem 270 30813-7.

 Kamath, A.V.; Vaaler, G.L.; Snell, E.E. (1991) Pyridoxal phosphate-dependent histidine decarboxylases. Cloning, sequencing, and expression of genes from Klebsiella planticola and Enterobacter aerogenes and properties of the overexpressed enzymes J Biol Chem 266 9432-7.

 Vaaler, G. L.; Brasch, M. A.; Snell, E. E. (1986) Pyridoxal 5'-phosphate-dependent histidine decarboxylase. Nucleotide sequence of the hdc gene and the corresponding amino acid sequence J Biol Chem 261 11010-4.

 Martin, S. A.; Bulfield, G. (1984) A structural gene (Hdc-s) for mouse kidney histidine decarboxylase Biochem Genet 22 645-56.

Articles on
last changed 2019/06/20 12:00

B6db activities