Activities | Families | Sequences | Fold types | References | Help
B6db activities:
Description Lysine racemase
Alternative names Broad specificity amino acid racemase (BAR) (ambiguous)
Catalyzed reaction L-lysine = D-lysine
Cofactor Pyridoxal-phosphate.
Comments The enzyme is involved in a lysine catabolic pathway.
Often a periplasmic enzyme. The enzyme is activated by divalent cations such as Mn2+.
Organisms -Eubacteria

Family (0) (0) (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Miyamoto T, Katane M, Saitoh Y, Sekine M, Homma H (2019) Elucidation of the D-lysine biosynthetic pathway in the hyperthermophile Thermotoga maritima FEBS J 286 601-614.

 Espaillat A., Carrasco-López C, Bernardo-García N, Pietrosemoli N, Otero LH, Álvarez L, de Pedro MA, Pazos F, Davis BM, Waldor MK, Hermoso JA, Cava F. (2014) Structural basis for the broad specificity of a new family of amino-acid racemases. Acta Crystallogr D Biol Crystallogr. 70 79-90.

 Palani K, Burley SK, Swaminathan S (2013) Structure of alanine racemase from Oenococcus oeni with bound pyridoxal 5'-phosphate Acta Crystallogr F Struct Biol Commun 69 15-9.

 Radkov AD, Moe LA (2013) Amino acid racemization in Pseudomonas putida KT2440 J Bacteriol 195 5016-24.

 Kato S, Hemmi H, Yoshimura T (2012) Lysine racemase from a lactic acid bacterium, Oenococcus oeni: structural basis of substrate specificity J Biochem 152 505-8.

 Wu HM, Kuan YC, Chu CH, Hsu WH, Wang WC. (2012) Crystal structures of lysine-preferred racemases, the non-antibiotic selectable markers for transgenic plants. PLoS One. 7 e48301.

 Kuan YC, Kao CH, Chen CH, Chen CC, Hu HY, Hsu WH (2011) Biochemical characterization of a novel lysine racemase from Proteus mirabilis BCRC10725 Process Biochem 46 1914-20.

 Matsui D, Oikawa T, Arakawa N, Osumi S, Lausberg F, Stäbler N, Freudl R, Eggeling L. (2009) A periplasmic, pyridoxal-5'-phosphate-dependent amino acid racemase in Pseudomonas taetrolens Appl Microbiol Biotechnol 83 1045-54.

 Kino K, Sato M, Yoneyama M, Kirimura K. (2007) Synthesis of DL-tryptophan by modified broad specificity amino acid racemase from Pseudomonas putida IFO 12996 Appl Microbiol Biotechnol 73 1299-305.

Articles on
last changed 2018/04/17 08:53

B6db activities