Activities | Families | Sequences | Fold types | References | Help
B6db activities: dsad

Description L-Isoleucine-3-epimerase (5.1.1.-)
Alternative names DsaD (gene name);
MfnO (gene name);
Catalyzed reaction L-isoleucine = L-allo-isoleucine
Cofactor Pyridoxal-phosphate, DsaE protein
DsaD from the desotamide biosynthetic pathway in Streptomyces scopuliridis, and MfnO from the marformycin biosynthetic pathway in Streptomyces drozdowiczii drive l-allo-Ile generation in each respective system.

Epimerase activity is conferred to these enzymes by a separate, small protein (termed DsaE in S. scopuliridis MfnH in S. drozdowiczii) which belongs to the NTF2_like superfamily and may be considered, in a sense, a cofactor for DsaD.

Organisms -Eubacteria


dsad (0)
Links Enzyme (activities) dsad
BRENDA (activities) dsad
KEGG (pathways) dsad
PLPMDB (PLP mutants) dsad
 Li Q, Qin X, Liu J, Gui C, Wang B, Li J, Ju J (2016) Deciphering the biosynthetic origin of L-allo-isoleucine J Am Chem Soc 138 408-15.

Articles on dsad
last changed 2018/04/11 13:13

B6db activities