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B6db activities: dsad

dsad
Description L-Isoleucine-3-epimerase (5.1.1.-)
Alternative names DsaD (gene name);
MfnO (gene name);
Catalyzed reaction L-isoleucine = L-allo-isoleucine
Cofactor Pyridoxal-phosphate, DsaE protein
DsaD from the desotamide biosynthetic pathway in Streptomyces scopuliridis, and MfnO from the marformycin biosynthetic pathway in Streptomyces drozdowiczii drive l-allo-Ile generation in each respective system.

Epimerase activity is conferred to these enzymes by a separate, small protein (termed DsaE in S. scopuliridis MfnH in S. drozdowiczii) which belongs to the NTF2_like superfamily and may be considered, in a sense, a cofactor for DsaD.

Organisms -Eubacteria
 

Family 

dsad (0)
 
Links Enzyme (activities) dsad
BRENDA (activities) dsad
KEGG (pathways) dsad
PLPMDB (PLP mutants) dsad
 
References
 Li Q, Qin X, Liu J, Gui C, Wang B, Li J, Ju J (2016) Deciphering the biosynthetic origin of L-allo-isoleucine J Am Chem Soc 138 408-15.

Articles on dsad
 
last changed 2018/04/11 13:13

B6db activities