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B6db families: 2.6.1.1.a

2.6.1.1 a
Activity 2.6.1.1
Description Aspartate aminotransferase. (family a)
Notes This aspartate aminotransferase subfamily includes functionally characterized enzymes from eukariotes.
PDB 7AAT;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
39
Sequences in seed alignment
FungiNP_593264 (Schizosaccharomyces pombe); XP_329457 (Neurospora crassa); EAK81244 (Ustilago maydis); EAA56559 (Magnaporthe grisea); AATC_YEAST (Saccharomyces cerevisiae); EAA63894 (Aspergillus nidulans);
MetazoaAATM_RAT (Rattus norvegicus); AAL06335 (Brugia malayi); AATC_HORSE (Equus caballus); AATC_CAEEL (Caenorhabditis elegans); AAH56110 (Xenopus laevis); AATM_CHICK (Gallus gallus); NP_725534 (Drosophila melanogaster); BAH05022 (Bubalus bubalis); AATC_CHICK (Gallus gallus); AATM_PIG (Sus scrofa); AAD47121 (Caenorhabditis elegans); CAE69898 (Caenorhabditis briggsae); AATM_HORSE (Equus caballus); AATM_HUMAN (Homo sapiens); 3HLM (Gallus gallus); NP_956283 (Danio rerio); AATC_RAT (Rattus norvegicus); AATC_PIG (Sus scrofa); AATC_HUMAN (Homo sapiens); CAF94552 (Tetraodon nigroviridis);
Other_EukaryaAAK73814 (Crithidia fasciculata); AF416601 (Leishmania mexicana); AAK73815 (Trypanosoma brucei);
ViridiplantaeAATC_ORYSA (Oryza sativa); AAT1_MEDSA (Medicago sativa); JC5125 (Oryza sativa); AAT1_ARATH (Arabidopsis thaliana); AAT5_ARATH (Arabidopsis thaliana); AATC_DAUCA (Daucus carota); AAT3_ARATH (Arabidopsis thaliana); AAT2_ARATH (Arabidopsis thaliana); AAC50014 (Glycine max); AATM_LUPAN (Lupinus angustifolius);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence AATC_YEAST
Domain interval 30-405
Catalytic site 255 K
 
References
 Muhammad Shahid Nadeem, Naeem Rashid, Muzaffar Iqbal, Qurra-tul-Ann Afza Gardner, Muhammad Akhtar (2011) First cloning and characterization of aspartate aminotransferase from river buffalo (Bubalus bubalis) Biologia 66 1202-1210.

 Gebhardt, J.S.; Wadsworth, G.J.; Matthews, B.F. (1998) Characterization of a single soybean cDNA encoding cytosolic and glyoxysomal isozymes of aspartate aminotransferase Plant Mol Biol 37 99-108.

 Jeffery, C. J.; Barry, T.; Doonan, S.; Petsko, G. A.; Ringe, D. (1998) Crystal structure of Saccharomyces cerevisiae cytosolic aspartate aminotransferase Protein Sci 7 1380-7.

 Reynolds, P. H.; Smith, L. A.; Dickson, J. M.; Jones, W. T.; Jones, S. D.; Rodber, K. A.; Carne, A.; Liddane, C. P. (1992) Molecular cloning of a cDNA encoding aspartate aminotransferase-P2 from lupin root nodules Plant Mol Biol 19 465-72.

 Udvardi, M. K.; Kahn, M. L. (1991) Isolation and analysis of a cDNA clone that encodes an alfalfa (Medicago sativa) aspartate aminotransferase Mol Gen Genet 231 97-105.

 Mattes, U.; Jaussi, R.; Ziak, M.; Juretic, N.; Lindenmann, J. M.; Christen, P. (1989) Structure of cDNA of cytosolic aspartate aminotransferase of chicken and its expression in E. coli Biochimie 71 411-6.

 Nagashima, F.; Tanase, S.; Fukumoto, Y.; Joh, T.; Nomiyama, H.; Tsuzuki, T.; Shimada, K.; Kuramitsu, S.; Kagamiyama, H.; Morino, Y. (1989) cDNA cloning and expression of pig cytosolic aspartate aminotransferase in Escherichia coli: amino-terminal heterogeneity of expressed products and lack of its correlation with enzyme function Biochemistry 28 1153-60.

 Horio, Y.; Tanaka, T.; Taketoshi, M.; Nagashima, F.; Tanase, S.; Morino, Y.; Wada, H. (1988) Rat cytosolic aspartate aminotransferase: molecular cloning of cDNA and expression in Escherichia coli J Biochem (Tokyo) 103 797-804.

 Martini, F.; Angelaccio, S.; Barra, D.; Pascarella, S.; Maras, B.; Doonan, S.; Bossa, F. (1985) The primary structure of mitochondrial aspartate aminotransferase from human heart Biochim Biophys Acta 832 46-51.

 Barra, D.; Bossa, F.; Doonan, S.; Fahmy, H. M.; Hughes, G. J.; Martini, F.; Petruzzelli, R.; Wittmann-Liebold, B. (1980) The cytosolic and mitochondrial aspartate aminotransferases from pig heart. A comparison of their primary structures, predicted secondary structures and some physical properties Eur J Biochem 108 405-14.

Articles on 2.6.1.1.a
last changed 2007/10/23 14:30

B6db families