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4.2.1.22
Activity 4.2.1.22
Description Cystathionine beta-synthase
Notes Mammalian cystathionine beta-synthases, but not the yeast enzyme, also bind a heme molecule.
Additional_domain CBS_HUMAN 1-400
PDB 1JBQ;1M54;4L0D;5OHX;
PLP Fold Type II
PLP-dependent Domain
Domain alignment
Domain hmm		Fold type II
Number of sequences 24
Sequences in seed alignment
BacteriaZP_00059346 (Thermobifida fusca); AAG48621 (Streptomyces venezuelae); AAN24961 (Bifidobacterium longum); AAS03341 (Mycobacterium avium); CAB89449 (Streptomyces coelicolor A3(2)); NP_215593 (Mycobacterium tuberculosis); CAE81156 (Bdellovibrio bacteriovorus); BAB96806 (Rhodococcus erythropolis);
FungiAF422799 (Magnaporthe grisea); AAL09565 (Pichia pastoris); CBS_YEAST (Saccharomyces cerevisiae); EAA78329 (Gibberella zeae); EAA30070 (Neurospora crassa); EAK93698 (Candida albicans);
MetazoaCBS_RAT (Rattus norvegicus); CBS_HUMAN (Homo sapiens); AAH44091 (Xenopus laevis); NP_001035353 (Apis mellifera); AAF50862 (Drosophila melanogaster); AAD13393 (Takifugu rubripes);
Other_EukaryaAAF71541 (Leishmania tarentolae); AAK16397 (Trypanosoma cruzi); AAN31486 (Phytophthora infestans); CBS_DICDI (Dictyostelium discoideum);

DISPLAY: Fasta format, alignment, hmm, hmm_local
Reference sequence CBS_HUMAN
Domain interval 80-376
Catalytic site 119 K
 
References
 Chang Z, Vining LC (2002) Biosynthesis of sulfur-containing amino acids in Streptomyces venezuelae ISP5230: roles for cystathionine beta-synthase and transsulfuration Microbiology 148 2135-2147.

 Li, D. Y.; Ji, X. S.; Yu, J.; Chen, M. J.; Yuan, Z. Y. (2001) PCR Based Cloning and Sequence Analysis of the Pichia pastoris Cystathionine beta-Synthase Gene Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 33 600-606.

 Nozaki, T.; Shigeta, Y.; Saito-Nakano, Y.; Imada, M.; Kruger, W.D. (2001) Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine beta-synthase and serine acetyltransferase from Trypanosoma J Biol Chem 276 6516-23.

 Jhee, K. H.; McPhie, P.; Miles, E. W. (2000) Yeast cystathionine beta-synthase is a pyridoxal phosphate enzyme but, unlike the human enzyme, is not a heme protein J Biol Chem 275 11541-4.

 Bukovska, G.; Kery, V.; Kraus, J. P. (1994) Expression of human cystathionine beta-synthase in Escherichia coli: purification and characterization Protein Expr Purif 5 442-8.

Articles on 4.2.1.22
last changed 2018/03/06 13:28

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