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B6db families: 5.1.1.18

5.1.1.18
Activity 5.1.1.18
Description Serine racemase.
Notes Validated eukaryotic enzymes (from metazoa and plants) are similar in sequence to serine ammonia-lyases (4.3.1.17), and in fact they often catalyze dehydration of serine to pyruvate in addition to serine racemization.
In bacteria, amino acid racemization is usually carried out by fold-type III enzymes (that we have grouped in the 5.1.1.1 family).
PLP Fold Type II
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type II

Number of sequences
12
Sequences in seed alignment
MetazoaXP_603692 (Bos taurus); BAC84968 (Rattus norvegicus); SRR_HUMAN (Homo sapiens); SRR_MOUSE (Mus musculus);
Other_EukaryaXP_003291791 (Dictyostelium purpureum); Q54HH2 (Dictyostelium discoideum); XP_004350026 (Dictyostelium fasciculatum); EFA82100 (Polysphondylium pallidum PN500);
ViridiplantaeCAD41643 (Oryza sativa); BAE72067 (Arabidopsis thaliana); BAF63026.1 (Hordeum vulgare); AAT42169 (Sorghum bicolor);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence SRR_HUMAN
Domain interval 19-314
Catalytic site 56 K
 
References
 Ito T, Murase H, Maekawa M, Goto M, Hayashi S, Saito H, Maki M, Hemmi H, Yoshimura T. (2012) Metal ion dependency of serine racemase from Dictyostelium discoideum. Amino Acids. 43 1567-76.

Articles on 5.1.1.18
last changed 2007/12/17 17:03

B6db families