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2.3.1.37
Activity 2.3.1.37
Description 5-aminolevulinic acid synthase.
Notes A very compact and distinct family of enzymes from eukarya (fungi-metazoa) and eubacteria.
PDB 1H7J;1H7D;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm		Fold type I
Number of sequences
30
Sequences in seed alignment
BacteriaD87417 (Caulobacter crescentus); HEM1_PARDE (Paracoccus denitrificans); HEM1_RHOCA (Rhodobacter capsulatus); HEM1_RHIME (Rhizobium meliloti); HEM1_BRAJA (Bradyrhizobium japonicum); HEM1_AGRRD (Agrobacterium radiobacter); HEM0_RHOSH (Rhodobacter sphaeroides); AF3452 (Brucella melitensis); HEM1_RHOSH (Rhodobacter sphaeroides); ZP_00303686 (Novosphingobium aromaticivorans); AAR83718 (Rhodopseudomonas palustris);
FungiHEM1_CANAL (Candida albicans); HEM1_EMENI (Emericella nidulans); AAD38391 (Aspergillus oryzae); HEM1_AGABI (Agaricus bisporus); HEM1_YEAST (Saccharomyces cerevisiae); HEM1_KLULA (Kluyveromyces lactis);
MetazoaHEM0_CHICK (Gallus gallus); AAD20808 (Sepia officinalis); HEM0_OPSTA (Opsanus tau); HEM1_RAT (Rattus norvegicus); HEM0_MOUSE (Mus musculus); HEM0_HUMAN (Homo sapiens); AD20807 (Glycera dibranchiata); HEM0_BRARE (Danio rerio); HEM1_CHICK (Gallus gallus); CAA74915 (Drosophila melanogaster); HEM1_HUMAN (Homo sapiens); HEM1_OPSTA (Opsanus tau); HEM0_RAT (Rattus norvegicus);

DISPLAY: Fasta format, alignment, hmm, hmm_local
Reference sequence HEM0_MOUSE
Domain interval 189-536
Catalytic site 391 K
 
References
 Astner I, Schulze JO, van den Heuvel J, Jahn D, Schubert WD, Heinz DW. (2005) Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans EMBO J 24 3166-77.

 Elrod, S.L.; Jones, A.; Berka, R.M.; Cherry, J.R. (2000) Cloning of the Aspergillus oryzae 5-aminolevulinate synthase gene and its use as a selectable marker Curr Genet 38 291-98.

 Bolt, E. L.; Kryszak, L.; Zeilstra-Ryalls, J.; Shoolingin-Jordan, P. M.; Warren, M. J. (1999) Characterization of the rhodobacter sphaeroides 5-aminolaevulinic acid synthase isoenzymes, HemA and HemT, isolated from recombinant Escherichia coli Eur J Biochem 265 290-9.

 Ferreira, G. C.; Dailey, H. A. (1993) Expression of mammalian 5-aminolevulinate synthase in Escherichia coli. Overproduction, purification, and characterization J Biol Chem 268 584-90.

Articles on 2.3.1.37
last changed 2008/05/20 11:50

B6db families