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B6db families:
Description 5-aminolevulinic acid synthase.
Notes A very compact and distinct family of enzymes from eukarya (fungi-metazoa) and eubacteria.
PDB 1H7J;1H7D;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
Sequences in seed alignment
BacteriaAF3452 (Brucella melitensis); ZP_00303686 (Novosphingobium aromaticivorans); AFU07636 (Rhodopseudomonas palustris); D87417 (Caulobacter crescentus); HEM1_RHOCA (Rhodobacter capsulatus); HEM1_RHIME (Rhizobium meliloti); AAR83718 (Rhodopseudomonas palustris); HEM1_RHOSH (Rhodobacter sphaeroides); HEM1_BRAJA (Bradyrhizobium japonicum); HEM0_RHOSH (Rhodobacter sphaeroides); HEM1_AGRRD (Agrobacterium radiobacter); HEM1_PARDE (Paracoccus denitrificans);
FungiHEM1_AGABI (Agaricus bisporus); HEM1_YEAST (Saccharomyces cerevisiae); HEM1_EMENI (Emericella nidulans); HEM1_KLULA (Kluyveromyces lactis); AAD38391 (Aspergillus oryzae); HEM1_CANAL (Candida albicans);
MetazoaAD20807 (Glycera dibranchiata); HEM1_HUMAN (Homo sapiens); HEM1_CHICK (Gallus gallus); HEM1_RAT (Rattus norvegicus); HEM0_HUMAN (Homo sapiens); AAD20808 (Sepia officinalis); HEM0_OPSTA (Opsanus tau); HEM0_RAT (Rattus norvegicus); CAA74915 (Drosophila melanogaster); HEM0_MOUSE (Mus musculus); HEM1_OPSTA (Opsanus tau); HEM0_BRARE (Danio rerio); HEM0_CHICK (Gallus gallus);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence HEM0_MOUSE
Domain interval 189-536
Catalytic site 391 K
 Zhang L, Chen J, Chen N, Sun J, Zheng P, Ma Y. (2013) Cloning of two 5-aminolevulinic acid synthase isozymes HemA and HemO from Rhodopseudomonas palustris with favorable characteristics for 5-aminolevulinic acid production. Biotechnol Lett. 35 763-8.

 Astner I, Schulze JO, van den Heuvel J, Jahn D, Schubert WD, Heinz DW. (2005) Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans EMBO J 24 3166-77.

 Elrod, S.L.; Jones, A.; Berka, R.M.; Cherry, J.R. (2000) Cloning of the Aspergillus oryzae 5-aminolevulinate synthase gene and its use as a selectable marker Curr Genet 38 291-98.

 Bolt, E. L.; Kryszak, L.; Zeilstra-Ryalls, J.; Shoolingin-Jordan, P. M.; Warren, M. J. (1999) Characterization of the rhodobacter sphaeroides 5-aminolaevulinic acid synthase isoenzymes, HemA and HemT, isolated from recombinant Escherichia coli Eur J Biochem 265 290-9.

 Ferreira, G. C.; Dailey, H. A. (1993) Expression of mammalian 5-aminolevulinate synthase in Escherichia coli. Overproduction, purification, and characterization J Biol Chem 268 584-90.

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last changed 2008/05/20 11:50

B6db families