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B6db families: 2.6.1.2.b
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2.6.1.2 b
Activity 2.6.1.2
Description Alanine aminotransferase. (family b)
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm		Fold type I
Number of sequences
19
Sequences in seed alignment
FungiXP_720174 (Candida albicans); ALAT_SCHPO (Schizosaccharomyces pombe ); ALAM_YEAST (Saccharomyces cerevisiae); ALAT_YEAST (Saccharomyces cerevisiae); EAA28376 (Neurospora crassa);
MetazoaALAT_HUMAN (Homo sapiens); EAA12069 (Anopheles gambiae); ALAT_RAT (Rattus norvegicus); NP_597700.1 (Homo sapiens); AAF48262 (Drosophila melanogaster); XP_128019.1 (Mus musculus); ALAT2_MOUSE (Mus musculus); CAB95577 (Trypanosoma brucei); NP_491690 (Caenorhabditis elegans);
ViridiplantaeNP_565040.1 (Arabidopsis thaliana); ALA2_PANMI (Panicum miliaceum); T08064 (Chlamydomonas reinhardtii); ALA2_HORVU (Hordeum vulgare); AAC62456 (Zea mays);

DISPLAY: Fasta format, alignment, hmm, hmm_local
Reference sequence ALAT_HUMAN
Domain interval 87-433
Catalytic site 313 K
 
References
 Rajamohan, F.; Nelms, L.; Joslin, D.L.; Lu, B.; Reagan, W.J.; Lawton, M. (2006) cDNA cloning, expression, purification, distribution, and characterization of biologically active canine alanine aminotransferase-1 Protein Expr Purif 48 81-9.

 Jadhao SB, Yang RZ, Lin Q, Hu H, Anania FA, Shuldiner AR, Gong DW. (2004) Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver Hepatology 39 1297-302.

 Yang, R.Z. Blaileanu, G. Hansen, B.C. Shuldiner, A.R. Gong, D.W. (2002) cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase Genomics 79 445-50.

 Chen, Z.Y.; Burow, M.D.; Mason, C.B.; Moroney, J.V. (1996) A low-CO2-inducible gene encoding an alanine: alpha-ketoglutarate aminotransferase in Chlamydomonas reinhardtii Plant Physiol 112 677-84.

 Muench, D.G.; Good, A.G. (1994) Hypoxically inducible barley alanine aminotransferase: cDNA cloning and expression analysis Plant Mol Biol 24 417-27.

 Ishiguro, M.; Takio, K.; Suzuki, M.; Oyama, R.; Matsuzawa, T.; Titani, K. (1991) Complete amino acid sequence of human liver cytosolic alanine aminotransferase (GPT) determined by a combination of conventional and mass spectral methods Biochemistry 30 10451-7.

Articles on 2.6.1.2.b
last changed 2008/10/10 16:31

B6db families