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B6db families: b
Description Alanine aminotransferase (family b)
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences 23
Sequences in seed alignment
FungiALAM_YEAST (Saccharomyces cerevisiae); ALAT_SCHPO (Schizosaccharomyces pombe ); XP_720174 (Candida albicans); XP_455940 (Kluyveromyces lactis ); EAA28376 (Neurospora crassa);
MetazoaEAA12069 (Anopheles gambiae); AAF48262 (Drosophila melanogaster); NP_491690 (Caenorhabditis elegans); ALAT_RAT (Rattus norvegicus); ALAT2_MOUSE (Mus musculus); XP_128019 (Mus musculus); ALAT1_HUMAN (Homo sapiens); ALAT_DOG (Canis lupus familiaris); NP_597700 (Homo sapiens);
Other_EukaryaXP_001219089 (Trypanosoma brucei);
ViridiplantaeNP_565040 (Arabidopsis thaliana); T08064 (Chlamydomonas reinhardtii); AAC62456 (Zea mays); AAF82782 (Arabidopsis thaliana); ALA2_HORVU (Hordeum vulgare); BBD74338 (Hordeum vulgare); AET01924 (Medicago truncatula); ALA2_PANMI (Panicum miliaceum);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence ALAT1_HUMAN
Domain interval 87-433
Catalytic site 340 K
 Escalera-Fanjul X, Campero-Basaldua C, Colón M, González J, Márquez D, González A. (2017) Evolutionary Diversification of Alanine Transaminases in Yeast: Catabolic Specialization and Biosynthetic Redundancy Front Microbiol 8 1150.

 McAllister CH, Facette M, Holt A, Good AG. (2013) Analysis of the enzymatic properties of a broad family of alanine aminotransferases PLoS One 8 e55032.

 Rajamohan, F.; Nelms, L.; Joslin, D.L.; Lu, B.; Reagan, W.J.; Lawton, M. (2006) cDNA cloning, expression, purification, distribution, and characterization of biologically active canine alanine aminotransferase-1 Protein Expr Purif 48 81-9.

 Jadhao SB, Yang RZ, Lin Q, Hu H, Anania FA, Shuldiner AR, Gong DW. (2004) Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver Hepatology 39 1297-302.

 Yang, R.Z. Blaileanu, G. Hansen, B.C. Shuldiner, A.R. Gong, D.W. (2002) cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase Genomics 79 445-50.

 Chen, Z.Y.; Burow, M.D.; Mason, C.B.; Moroney, J.V. (1996) A low-CO2-inducible gene encoding an alanine: alpha-ketoglutarate aminotransferase in Chlamydomonas reinhardtii Plant Physiol 112 677-84.

 Muench, D.G.; Good, A.G. (1994) Hypoxically inducible barley alanine aminotransferase: cDNA cloning and expression analysis Plant Mol Biol 24 417-27.

 Son D, Sugiyama T (1992) Molecular cloning of an alanine aminotransferase from NAD-malic enzyme type C4 plant Panicum miliaceum Plant Mol Biol 20 705-13.

 Ishiguro, M.; Takio, K.; Suzuki, M.; Oyama, R.; Matsuzawa, T.; Titani, K. (1991) Complete amino acid sequence of human liver cytosolic alanine aminotransferase (GPT) determined by a combination of conventional and mass spectral methods Biochemistry 30 10451-7.

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last changed 2020/02/27 20:03

B6db families