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4.2.1.22
Activity 4.2.1.22
Description Cystathionine beta-synthase.
Notes Mammalian cystathionine beta-synthases, but not the yeast enzyme, also bind a heme molecule.
Additional_domain CBS_HUMAN 1-400
PDB 1JBQ;1M54;
PLP Fold Type II
PLP-dependent Domain
Domain alignment
Domain hmm		Fold type II
Number of sequences
23
Sequences in seed alignment
BacteriaNP_215593 (Mycobacterium tuberculosis); AAN24961 (Bifidobacterium longum); CAB89449.1 (Streptomyces coelicolor A3(2)); AAG48621 (Streptomyces venezuelae); BAB96806.1 (Rhodococcus erythropolis); ZP_00059346 (Thermobifida fusca); AAS03341 (Mycobacterium avium); CAE81156 (Bdellovibrio bacteriovorus);
FungiCBS_YEAST (Saccharomyces cerevisiae); EAA30070 (Neurospora crassa); EAA78329 (Gibberella zeae); AAL09565 (Pichia pastoris); EAK93698 (Candida albicans); AF422799_1 (Magnaporthe grisea);
MetazoaCBS_HUMAN (Homo sapiens); AAK16397 (Trypanosoma cruzi); CBS_RAT (Rattus norvegicus); AAF50862 (Drosophila melanogaster); AAN31486 (Phytophthora infestans); AAD13393 (Takifugu rubripes); AAH44091 (Xenopus laevis); AAF71541 (Leishmania tarentolae);
Other_EukaryaCBS_DICDI (Dictyostelium discoideum);

DISPLAY: Fasta format, alignment, hmm, hmm_local
Reference sequence CBS_HUMAN
Domain interval 80-376
Catalytic site 119 K
 
References
 Chang Z, Vining LC (2002) Biosynthesis of sulfur-containing amino acids in Streptomyces venezuelae ISP5230: roles for cystathionine beta-synthase and transsulfuration Microbiology 148 2135-2147.

 Li, D. Y.; Ji, X. S.; Yu, J.; Chen, M. J.; Yuan, Z. Y. (2001) PCR Based Cloning and Sequence Analysis of the Pichia pastoris Cystathionine beta-Synthase Gene Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 33 600-606.

 Nozaki, T.; Shigeta, Y.; Saito-Nakano, Y.; Imada, M.; Kruger, W.D. (2001) Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine beta-synthase and serine acetyltransferase from Trypanosoma J Biol Chem 276 6516-23..

 Jhee, K. H.; McPhie, P.; Miles, E. W. (2000) Yeast cystathionine beta-synthase is a pyridoxal phosphate enzyme but, unlike the human enzyme, is not a heme protein J Biol Chem 275 11541-4..

 Bukovska, G.; Kery, V.; Kraus, J. P. (1994) Expression of human cystathionine beta-synthase in Escherichia coli: purification and characterization Protein Expr Purif 5 442-8..

Articles on 4.2.1.22
last changed 2008/03/27 19:12

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