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B6db activities: 2.6.1.19

2.6.1.19
Description 4-aminobutyrate aminotransferase.
Alternative names Gamma-amino-butyrate transaminase;.
GABA transaminase;
Glutamate--succinic semialdehyde transaminase;
Beta-alanine--oxoglutarate aminotransferase.
Catalyzed reaction 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.
Cofactor Pyridoxal-phosphate.
Comments -!- Some preparations also act on beta-alanine, 5-aminopentanoate and (R,S)-3-amino-2-methylpropanoate.
The enzyme from rat liver seems to be identical to (S)-3-amino-2-methylpropanoate aminotransferase (2.6.1.22).
Diseases GABA-transaminase deficiency
Prosite PROSITE; PDOC00519;
PDB 1OHV; 1OHY;
Organisms -Eubacteria -Plants -Fungi -Metazoa -Human
 

Family 

2.6.1.19_a (14) 2.6.1.19_b (20)
 
Links Enzyme (activities) 2.6.1.19
BRENDA (activities) 2.6.1.19
KEGG (pathways) 2.6.1.19
PLPMDB (PLP mutants) 2.6.1.19
 
References
 Andersen G, Andersen B, Dobritzsch D, Schnackerz KD, Piskur J. (2007) A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast FEBS J 274 1804-17.

 Liu W, Peterson PE, Carter RJ, Zhou X, Langston JA, Fisher AJ, Toney MD. (2004) Crystal structures of unbound and aminooxyacetate-bound Escherichia coli gamma-aminobutyrate aminotransferase Biochemistry 43 10896-905.

 Belitsky, B.R.; Sonenshein, A.L. (2002) GabR, a member of a novel protein family, regulates the utilization of gamma-aminobutyrate in Bacillus subtilis Mol Microbiol 45 569-83.

 Jeon, S.G.; Bahn, J.H.; Jang, J.S.; Jang, S.H.; Lee, B.R.; Lee, K.S.; Park, J.; Kang, T.C.; Won, M.H.; Kim, H.B.; Kwo, O.S.; Cho, S.W.; Choi, S.Y. (2001) Molecular cloning and functional expression of bovine brain GABA transaminase Mol Cells 12 91-6.

 Storici, P.; Capitani, G.; De Biase, D.; Moser, M.; John, R. A.; Jansonius, J. N.; Schirmer, T. (1999) Crystal structure of GABA-aminotransferase, a target for antiepileptic drug therapy Biochemistry 38 8628-34.

 Medina-Kauwe, L.K.; Tillakaratne, N.J.; Wu, J.Y.; Tobin, A.J. (1994) A rat brain cDNA encodes enzymatically active GABA transaminase and provides a molecular probe for GABA-catabolizing cells J Neurochem 62 1267-75.

 Park, J.; Osei, Y.D.; Churchich, J.E. (1993) Isolation and characterization of recombinant mitochondrial 4-aminobutyrate aminotransferase J Biol Chem 268 7636-9.

 Kwon, O. S.; Park, J.; Churchich, J. E. (1992) Brain 4-aminobutyrate aminotransferase. Isolation and sequence of a cDNA encoding the enzyme J Biol Chem 267 7215-6.

 Schulz, A.; Taggeselle, P.; Tripier, D.; Bartsch, K. (1990) Stereospecific production of the herbicide phosphinothricin (glufosinate) by transamination: isolation and characterization of a phosphinothricin-specific transaminase from Escherichia coli Appl Environ Microbiol 56 1-6.

 Tamaki, N.; Fujimoto, S.; Mizota, C.; Kikugawa, M. (1987) Identity of beta-alanine-oxo-glutarate aminotransferase and L-beta- aminoisobutyrate aminotransferase in rat liver Biochim Biophys Acta 925 238-40.

Articles on 2.6.1.19
 
last changed 2010/09/03 13:31

B6db activities